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2-Oxo-PCE (AKA eticyclidone or O-PCE) is most similar to DCK — the only difference is that O-PCE has a one-carbon chain, while DCK has a 2-carbon chain in the same position. This difference is subtle but produces distinct changes in the effect profile. O-PCE (Eticyclidone).
Compared to DCK and ketamine, O-PCE is significantly more stimulating and has fewer inhibitory effects on the senses. This compound doesn’t normally exert its dissociative effects until 3 or 4 hours into the trip as it begins to wear off.
Because of the stimulating nature of this compound, O-PCE is often referred to as “chaotic” and “wonky,” — producing unexpected urges and bizarre behavior — especially in higher doses. In low to moderate doses, it’s usually described as warm and euphoric, with less of the heavy dissociative effects of other drugs like DCK or ketamine. O-PCE (2-Oxo-PCE, Eticyclidone).
The receptor Ki values for O-PCE have not yet been reported.
O-PCE SPECS:
| Chemical Name | N-ethyldeschloroketamine |
| Status | Research Chemical 🧪 |
| Duration of Effects | 3–6 hours |
| Estimated Threshold Dose | 1 mg |
| Common Dose | 3–15 mg (Oral & Insufflated) |
| PubChem ID | 132989542 |
| CAS# | 6740-82-5 |
WHAT IS DISSOCIATIVE DRUGS? – O-PCE (Eticyclidone)
Dissociative drugs (AKA ‘dissos’) are substances that decouple one’s first-person experience from reality. They dismantle the idea of “self” and alter one’s perception of reality. O-PCE (2-Oxo-PCE, Eticyclidone)
Some dissociative reliably induce states that feel enlightening and enjoyable; others produce powerful hallucinogenic experiences that are almost always terrifying and traumatizing. Buy O-PCE. Magic mushrooms online store
The effects of these substances vary by dose and substance — sometimes, users feel like they’re outside their body as a detached observer; other times, they’re injected into what feels like a separate reality entirely. Buy o-pce powder.
Dissociative drugs have conflicting effects — they’re stimulating and sedating, neuroprotective [6], and neurotoxic, and have addictive and anti-addictive [7] qualities. The effect comes down largely to which drug is being used, how often, and in what dose.
WHAT DO DISSOCIATIVE DRUGS FEEL LIKE
The main feeling shared by all dissociatives is the detachment from the self or from the environment. This is the central component linking all dissociative substances together. The other effects depend on each individual substance.
Dissociative drugs tend to be very strong compared to other psychedelics. Their capacity to alter the perception of one’s physical reality is comparable to the potency of DMT or salvia. Pennsylvania mushroom shop
Users often feel like they’ve teleported to another location or that the world around them has dissolved into nothingness.
Explaining the effects of deep dissociative states is no easy task. Language itself often proves insufficient for explaining these experiences.
Here are a few examples of people’s reports involving dissociative drug experiences:
- “It’s all close and far at the same time.”
- “My body died, but my mind had it’s own legs.”
- “I was caught in an endless time loop with my dad examining my fingerprints.”
- “I visited a place outside of time.”
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Therefore, people who use dissociatives will experience dream-like states of consciousness, including blurriness, difficulty making sense of events, confusion, detachment from emotion, and lapses in memory.
At the bottom of the dissociative state is a feeling of complete isolation and loneliness, but this state isn’t as uncomfortable as it sounds. Because of the lack of identity and absence of attachment, users feel as though they’re in a state of perfect zen.
Common experiences with dissociative drugs:
- Feeling like one is teleported to another location or dimension
- Secondly, loss of touch with the self & one’s identity
- Thirdly, feeling like the limbs are being pulled & stretched
- Fourthly, feeling like one is dissolving or exploding
- Observing oneself from outside the body
- Loss of touch with one’s emotional connection to objects, people, or locations
- Hallucinations of dark & malicious creatures or figures
- Paranoid or grandiose ideologies
- Tingling, numbing, or floating sensations throughout the body
- Lastly, loss of depth perception or flattening of the visual field
HOW DISSOCIATIVE DRUGS WORK – O-PCE (Eticyclidone)
Firstly, most dissociatives produce the majority of their psychoactive effects by blocking the NMDA receptors. This is the primary mechanism of action for DXM, PCP, ketamine, nitrous oxide, MXE, xenon gas, and many others in this class.
Very high doses of classical psychedelics, including LSD, 2C-X compounds, DMT, and psilocybin, can also cause dissociation through the 5HT2A receptors — but this experience feels very different than dissociation caused by NMDA receptor antagonism.





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