FREQUENTLY ASKED QUESTIONS

1. What’s the Strongest Arylcyclohexylamine Psychedelic?

The strongest arylcyclohexylamine in NMDA-binding affinity is 3-MeO-PCPr with a Ki value of 17.9 nM, followed by 3-MeO-PCPy, 3-HO-PCE, 3,4-MD-PCPr, and 3-HO-PCP.

This drug class is not well studied, and there are only a small handful of unofficial trip reports available for the vast majority of these substances. This makes it difficult to definitively rank the potency of this class. We believe the best way to make an educated guess is to compare the NMDA activity.

However, other variables play a role as well, such as bioavailability, SERT, DAT, NET, sigma-1 and sigma-2, and nACHr binding activity. All of these receptors collaborate to produce the resulting effects of these drugs, so this list is not definitive. PCE (ETICYCLIDINE).

We will update this list as more information becomes available.

Estimated ranking of arylcyclohexylamines in order of potency: 

1. 2-MeO-PCMo
2. 3′-MeO-PCPr
3. 3′-MeO-PCPy
4. 3′-HO-PCE
5. 3′,4′-MD-PCPr
6. 3′-HO-PCP
7. 3′-MeO-PCE
8. 3′,4′-MD-PCE
9. 3′-MeO-PCP
10. 3′-Me-PCE
11. 3′-Me-PCPr
12. PCP (Phencyclidine)
13. 3′,4′-MD-PCP
14. 3′-MeO-PCMe
15. 3′-Me-PCMo
16. 3′-MeO-PCMo
17. MXE (Methoxetamine)
18. Ketamine
19. PcMo
20. 3′,4′-MD-PCMo
    

    4. How Do You Pronounce Arylcyclohexylamine?

    Arylcyclohexylamine is pronounced as “air-il-sigh-kloh-hex-ih-luh-meen.”

    5. What Do Dissociatives Feel Like?

    Dissociatives cause users to feel like they’ve been disconnected from their bodies and/or the environment around them. They’re sometimes teleported to a different location, or may feel like they’re sitting somewhere outside their body — either watching themselves or simply aware that their body is no longer present.

    Most users find it difficult to describe the dissociative experience following a trip because it often requires the use of nonsensical language like “I visited a place outside of time” or “everything was close and far at the same time.”

    Of course, none of this makes sense using verbal language, but the dissociative experience can very easily cause these kinds of paradoxical or nonsensical sensations. PCE (ETICYCLIDINE).

    The dissociative state manifests differently for everybody, but some common descriptions of this state include the following:

    • Feeling like you’re watching yourself from somewhere else
    • Feeling like you’re outside your body — sometimes control of the body is maintained, other times the body appears to act on autopilot
    • Time doesn’t make sense — something that felt like hours could have taken place in a matter of seconds, and things that felt like a few seconds could have spanned several hours
    • Very strong closed and open-eye hallucinations may take place, especially with higher doses — the depths of the dissociative state are some of the most profoundly psychedelic experiences known
    • You may not recognize yourself in the mirror (frequent users often recommend avoiding looking in the mirror on dissociatives because this effect can be unsettling)
    • You may experience glimpses of past experiences flashing into your field of vision like a slideshow reel
    • You may remain grounded somewhat in reality or be removed from it entirely

    6. What is the Mechanism of Action For Dissociatives?

    Firstly, the primary mechanism of action for dissociative drugs is a blockage of the NMDA receptors. This prevents glutamate from binding to these receptors resulting in widespread interruptions in neurotransmission in the higher regions of the brain. PCE (ETICYCLIDINE).

    Other factors involved include the activation of the kappa-, mu-, and delta-opioid receptors, activation of the dopaminergic receptors, activation of the sigma-1 and sigma-2 receptors, and inhibition of the dopamine, serotonin, and norepinephrine transporters.

    8. What Other Drugs Act As Dissociatives?

    Therefore, other drugs with dissociative effects include nitrous oxide and xenon gas, MK-801, and dextromethorphan (DXM).

    Alcohol, gamma-hydroxybutyrate (GHB), and some benzodiazepines can also exert a dissociative-like effect — but these drugs are nowhere near as strong as the others mentioned above. PCE (ETICYCLIDINE).

    9. Which Arylcyclohexylamines Can Be Vaped?

    Most arylcyclohexylamines can be vaped or smoked. In fact, this is one of the primary modes of administration people use for taking PCP.

    There is no safety information on vaporizing arylcyclohexylamines, so it’s unclear what the short or long-term health consequences may be.

    One salient danger of this method of administration is that any heat-stable members of this group will likely be much stronger when smoked — and kick in much quicker. This could make overdosing much more likely if people are not very careful with their consumption.

    Other substances may not be heat stable and will have little to no effect when vaped. More information is needed. PCE (ETICYCLIDINE).

    10. When Was the First Arylcyclohexylamine Invented? 

    The first arylcyclohexylamine ever reported is a compound called 1-(1-Phenylcyclohexyl)amine (PCA), which was reported back in 1907. This compound is the precursor to PCP and many other members of the group.

    Nearly half a century later, the second arylcyclohexylamine, N-ethyl-1-phenylcyclohexylamine (PCE), was discovered in 1953. This kicked off a chain reaction of research on this group. The following year 1-(1-Phenylcyclohexyl)morpholine (PCMo) was included in a German patent.

    Two years later, in 1956, PCP was discovered by Victor Maddox while working for Parke-Davis. This was the first arylcyclohexylamine to make it to market (approved in 1957).

    A few years later, in 1962, Calvin L. Stevens (also working for Parke Davis as a consultant) discovered 2-oxo-PCE in 1962. Stevens’ lab later developed ketamine, which went on to become the most successful arylcyclohexylamine produced by Parke Davis.